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Evidence is increasing that all addiction without exception is related to issues with the brain's reward center, particularly the mesolimbic system. This part of the problem regulates reward responses in getting food and sex, plus nurturing infants and children. One of the most important neurotransmitters involved in reward responses, both once they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the amount of dopamine released in in response to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to lose weight naturally can be very effective there are combinations as you're watching FDA now awaiting approval. When dealing with fat loss and the people that go through it you should err on the side of caution and permit the FDA do its job and demand some research be done so that the public is aware of the side effects and risks of the medications before we drive them. Keep in mind that drug companies have been in business to generate income and that they would say anything to keep people on their own medications.

Researchers discovered that participants taking this drug for any year, lost weight within 4 weeks and have kept the body weight off throughout the 56 weeks in the study. Contrave is really a combination from the drugs naltrexone and bupropion, which generally seems to reflect a whole new trend of weight-loss drugs which can be made up of multiple active ingredient, which might make them more potent and safer.

Combo-pilling is the newest fad or better yet the newest into the future under scrutiny and so it is just more publicly known lately, comb-pilling for weight reduction has been around since the eighties. The biggest reason that employing a combination of pills is starting to become popular will be the fact that as of right now there are no long term prescription slimming capsules that have been approved by the FDA other than orlistat. The truly disturbing part is doctors are prescribing these combinations of medications and some of the combinations happen to be rejected or have yet to be authorized by the FDA.

Seizures really are a side effect with Contrave and really should not be taken in people with seizure disorders. The drug can also raise blood pressure level and heartbeat, and must not be used in those with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy while using drug.

The FDA also warned that Contrave can raise blood pressure levels and heartrate and must stop used in patients with uncontrolled high blood pressure level, in addition to by a person with heart-related and cerebrovascular (blood vessel dysfunction impacting your brain) disease. Patients with a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes using a boxed warning to alert health care professionals and patients towards the increased chance of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stop smoking.

The most common side effects with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.